UC study: Alzheimer’s drug may work by boosting brain protein …
WEBSep 11, 2024 · During a study challenging the idea that newly approved monoclonal antibodies reduce cognitive decline in Alzheimer's patients by clearing amyloid, University of Cincinnati researchers found that the unintended increase in levels of a critical brain protein correlates equally well with cognitive benefits. Led by UC’s Alberto Espay, MD, the ...
Alzheimer's: Boosting brain protein may slow cognitive decline
WEB1 day ago · “Aβ42 is a protein that reacts to a variety of toxic and infectious exposures, in the process of defending the brain,” Espay explained. “In that process, Aβ42 transforms into amyloid ...
Boosting brain protein levels may slow decline from Alzheimer's
WEBSep 11, 2024 · For decades, the prevailing theory in the field has stated that a protein made up of 42 amino acids called amyloid-beta 42 (Aβ42) hardens into clumps called amyloid plaques, and those plaques ...
Alzheimer's decline may be slowed by protein boost
WEBSep 12, 2024 · National media outlets including Newsweek and U.S. News & World Report highlighted UC research led by Alberto Espay that found new monoclonal antibody drugs for Alzheimer’s may slow cognitive impairment through …
Increases in Brain Protein, Not Just Amyloid Clearance, Linked to ...
WEBSep 11, 2024 · The findings suggest that Aβ42 levels might play a crucial role in cognitive benefits from new treatments. Key Takeaways; Aβ42 Increase: New Alzheimer’s drugs that increase Aβ42 levels are linked to slower cognitive …
Study shows Alzheimer's drugs may boost protein, not just lower …
WEB6 days ago · Aβ42 is a protein that consists of 42 amino acids. The proteins can harden and bind together to form the brain tissue plaques linked with Alzheimer’s disease.
Alzheimer's Decline May Be Slowed by Protein Boost
WEBSep 11, 2024 · Previous research from Espay's lab has suggested that Alzheimer's does not occur as a direct result of these plaques. Instead, it appears to occur when there is not enough Aβ42. "Aβ42 is a ...
Patricidal Protein? Aβ42 said to Inhibit Its Parent, γ-Secretase
WEB17 Nov 2023. Neuritic plaques, tau phosphorylation, microgliosis—of all the ways Aβ42 could doom the brain, few scientists might have suspected that it cripples γ-secretase, the very enzyme that creates it. Yet that is just what monomers do, according to a manuscript uploaded to bioRxiv.
Plasma biomarkers predict Alzheimer’s disease before ... - Nature
WEBOct 24, 2023 · Plasma amyloid-β (Aβ)42, phosphorylated tau (p-tau)181, and neurofilament light chain (NfL) are promising biomarkers of Alzheimer’s disease (AD). However, whether these biomarkers can predict...
Alzheimer Disease Blood Biomarkers and Incident Dementia
WEBJul 28, 2024 · Decreasing Aβ42:Aβ40 ratio and increasing p-tau181, NfL, and GFAP were observed from midlife to late life, with more rapid biomarker changes among participants carrying the apolipoprotein E epsilon 4 (APOEε4) allele.