Figure 1: SDF-1 and FGF-4 restore platelet counts in TPO- or c-Mpl-deficient mice. Figure 2: SDF-1 and FGF-4 increase interaction of megakaryocytes with sinusoidal BMECs. Figure 3: SDF-1 and FGF-4 ...
Most current treatments for chronic immune thrombocytopenic purpura (ITP) act by decreasing platelet destruction. In a phase 1–2 study, we administered a thrombopoiesis-stimulating protein, AMG 531, ...
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