This study presents valuable findings on the role of KLF6 in in vitro endothelial cells exposed to altered (high or low) shear stress with a customized microfluidic device to investigate mechanisms of ...

Introduction: Hemodynamics and wall biomechanics jointly drive ascending-aortic remodeling in bicuspid aortic valve (BAV) disease, yet most in silico studies model only flow or strain. Manual ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. Many soft ...

The intrinsic ductility we have found offers fascinating insights from a purely scientific perspective. Unlike previous works, the strain hardening observed in our MPEMG (multiprincipal element ...

Hemodynamic shear stress, the frictional force exerted by blood flow on the endothelium, mediates vascular homeostasis. This review examines the biophysical nature and biochemical effects of shear ...

ABSTRACT: In the actual engineering of the structure, mechanical notch is inevitable, which will significantly reduce the fatigue life of the structure. In order to ensure the application of notch ...

The endothelial glycocalyx encompasses the entire endothelial cell, transducing extracellular signals and regulating vascular permeability and barrier functions. The apical glycocalyx, which forms the ...

State Key Laboratory of Coal Mine Safety Technology, China Coal Technology & Engineering Group Shenyang Research Institute, Shenfu Demonstration Zone, Shenyang 113122, China Key Laboratory of Ministry ...