New treatment option shows promise for severe hypertrophic cardiomyopathy in children
Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe ...
Medindia5h
Trametinib: Personalized Treatment for Pediatric Hypertrophic Cardiomyopathy
Discover Trametinib as a promising treatment for severe hypertrophic cardiomyopathy in children with RASopathies.
Medscape6d
Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology
In contrast, the signal proceeds normally or with greater strength (because of compensatory hyperinsulinemia of various degrees) along the Shc-Ras-MAP kinase pathway, eliciting greater responses ...
Quanta Announces IND Clearance by U.S. FDA for QTX3544, an Oral G12V-Preferring Multi-KRAS Inhibitor, and Other Pipeline Updates
Additionally, the Phase 1 clinical trial evaluating QTX3034, an oral G12D-preferring multi-KRAS inhibitor, as a monotherapy and in combination with cetuximab, continues to enroll patients, and data is ...
Pharmaceutical Technology2d
IMM-1-104 by Immuneering for Non-Small Cell Lung Cancer: Likelihood of Approval
IMM-1-104 is under clinical development by Immuneering and currently in Phase II for Non-Small Cell Lung Cancer.
eLife6d
Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition
Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...
Medscape4d
Intestinal Permeability – A New Target for Disease Prevention and Therapy
Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a ...
Yahoo Finance5d
Jazz Pharmaceuticals plc (JAZZ)
After hours: January 3 at 6:00:04 PM EST Loading Chart for JAZZ ...