Despite sequence differences between subfamily members, all Ras-related proteins are GTPases with five ... Nature, 366, 634–654. Bollag G and McCormick F . (1995). Methods Enzymol., ...

The N-terminal 164 residues of RAS proteins constitute the G domain (92–98% sequence identity) implicated in GTP binding and hydrolysis. The C-terminal 24/25 residues display the greatest ...

Bochum biophysicists in collaboration with the MPI Dortmund have for the first time measured the orientation of the Ras protein bound to the cell membrane. The RUB team combined the use of three ...

Ras proteins have long been the focus of cancer research because of their role as "on/off switch" signaling pathways that control cell division and failure to die like normal, healthy cells do. In ...

Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy.

Ras proteins act as a molecular "switch," flipping between active and inactive modes; they play a critical role in cell signaling and growth regulation and are often mutated in cancers.

They demonstrated that the Ras protein is important for setting the phase of such a circadian clock, as its activity determines the period length of the rhythm. Ras is also contributing to induce ...

Ras proteins are molecular switches that decide if and when cells divide inside our bodies. An impairment of their function may result in the formation of a tumor. The process of switching the ...

Mutated RAS drives the growth of tumors. This makes it an attractive therapeutic target.” The RAS family of proteins are mutated in nearly 20% of human tumors; however, there has been little progress ...