Despite sequence differences between subfamily members, all Ras-related proteins are GTPases with five ... Nature, 366, 634–654. Bollag G and McCormick F . (1995). Methods Enzymol., ...

G proteins of the Ras family cycle between GDP-bound inactive and GTP-bound active forms. This cycle is regulated by guanine nucleotide exchange factor (GEF), the activator, and GTPase activating ...

Ras proteins have long been the focus of cancer ... in the recruitment of the oncogene KRas4b" is authored by Stephen G. Sligar, Michael C. Gregory and Mark A. McLean. It will be presented at ...

Ras proteins have long been the focus of cancer ... in the recruitment of the oncogene KRas4b" authored by Stephen G. Sligar, Michael C. Gregory and Mark A. McLean.

Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy.

Malfunctions of the Ras protein can cause it to remain in an active state or switch off with a significant delay. This causes uncontrolled cell growth and, as a result, cancer.

These proof-of-principle findings were published on Feb. 8 in Cell Reports. This work, which involves inhibiting the oncogenic protein RAS using small molecules, lays a strong foundation for the ...

In addition, the decline in muscle mass with GLP-1 RAs is several times greater than ... The recommended dietary allowance (RDA) for protein is 0.8 g/kg for most adults, while the acceptable ...

A cancer-causing protein long thought to be resistant to medication could soon be the target of new drugs, thanks to the work of Quebec researchers who used synchrotron light to find and exploit ...

Renin–angiotensin system (RAS) inhibitors — including angiotensin ... or none), mean arterial pressure (<100 or ≥100 mm Hg), and proteinuria (protein:creatinine ratio, <885 or ≥885).