A cancer-causing protein long thought to be resistant to medication could soon be the target of new drugs, thanks to the work of Quebec researchers who used synchrotron light to find and exploit ...

To demonstrate the power of their model, the researchers applied it to two biologically significant systems: the RAS-RAF complex and G Protein-Coupled Receptors (GPCRs). The RAS-RAF complex plays ...

Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins ...

Hypertension is a major public health concern, affecting millions worldwide and increasing the risk of heart disease, stroke, and kidney failure.

Protein intake was individualized, but generally above the Dietary Reference Intake of 0.8 g/kg. They were assessed ... medications for use with GLP-1 RAs “will likely only be needed for ...

Combination treatment of QTX3544 with cetuximab significantly enhanced anti-tumor efficacy and elicited greater tumor regressions in pancreatic and colorectal KRAS G12V -mutant cell line-derived ...

Credit: Canadian Light Source The researchers found that when the Ras protein is in its mutated, cancer-causing state, "molecules snuggle inside the pocket. Using crystallography, we were able to ...