Explore new findings on ovarian cancer and how blocking focal adhesion kinase can enhance immune response in treatment.

Coronaviruses not only use the machinery of the human cells they infect: they modify them to achieve optimal conditions to ...

This important paper presents a rigorous and comprehensive deep mutational analysis of the kinase TYK2, revealing how single amino acid substitutions influence protein abundance, signaling activity, ...

Prospect Therapeutics Inc. has synthesized new substituted tricyclic derivatives acting as tyrosine-protein kinase JAK1 and non-receptor tyrosine-protein kinase TYK2 inhibitors.

A major international trial published in The Lancet Oncology has looked at studies from 13 head and neck cancer centers from nine countries around the world. Using the data of 7,895 patients, a ...

Most patients with vascular anomalies treated with the mitogen-activated protein kinase (MEK) inhibitors, trametinib and selumetinib, experienced cutaneous adverse events (CAEs). “Multidisciplinary ...

Protein kinases are the molecular switches of the cell. They control growth, division, communication, and survival by attaching phosphate groups to other proteins. When these switches are stuck in the ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Water-based pharmacophore modeling is an emerging approach in inhibitor design that ...

Heart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome with high morbidity and mortality. Empagliflozin, an SGLT2 (sodium–glucose cotransporter 2) inhibitor, reduces adverse ...

Mucin 16–Directed Therapy in Pediatric Sarcomas: Case Evidence of Ubamatamab Efficacy in Epithelioid Sarcoma and Its Implications for Other Sarcoma Subtypes We conducted a phase I trial of the ...