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Phosphatase and tensin homologue (PTEN)-mediated hydrolysis of PIP3 to PIP2 and P70S6K-induced phosphorylation of insulin receptor substrate 1 (IRS1) negatively controls the PI3K/AKT/mTOR pathway (88, ...

Secondary end points included evaluating RNAseq-based molecular subtypes, BRCA/HRD status, HER2 gene expression/signature, and PTEN loss signature associations ... stromal/EMT/TGFβ, RAS, angiogenesis, ...

In this infographic, learn how recent breakthroughs have allowed scientists to develop treatments that specifically target mutant K-Ras, the protein product of ... also mute genes related to immunity ...

For years, overshadowed by its neighboring emirates of Dubai and Abu Dhabi, Ras Al Khaimah (RAK) is now stepping into the spotlight as one of the UAE’s most promising real estate hotspots for ...

This article uncovers a new important role of STAMBPL1 in promoting angiogenesis in triple-negative breast cancer (TNBC) and elucidates the specific mechanisms by which it activates the ...

Keep reading: When you get this error, you will see the following message: The connection was prevented because of a policy configured on your RAS/VPN server. Specifically, the authentication ...

The most important signaling molecule identified in these patches of membrane is a protein called Ras, which is mutated and hyperactive in many different types of cancer. In Dictyostelium cells that ...