A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health traits. By probing regions of DNA previously linked to disease, the work has ...

This study reports an important and novel finding that TENT5A, an enzyme involved in fine-tuning poly(A) tail length on selected mRNAs, is required for proper enamel mineralization in mice. The ...

A research team led by UAB researcher David Reverter has discovered the molecular mechanism that describes in detail the ...

Researchers at the School of Biological Sciences of The University of Hong Kong (HKU) have uncovered how eukaryotic cells can control gene activity even after losing one of their major gene-regulatory ...

Gene regulation is far more predictable than previously believed, scientists conclude after developing the deep learning model PARM. This might bring an end to a scientific mystery: how genes know ...

Aurora Therapeutics' first target is the rare inherited disease phenylketonuria, also known as PKU. Here at MIT Technology Review we’ve been writing about the gene-editing technology CRISPR since 2013 ...

Abstract: Single-cell RNA sequencing (scRNA-seq) allows gene expression to be measured at single-cell resolution, offering new opportunities to investigate Gene Regulatory Networks (GRNs), which ...

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders - including cancers, neurodegenerative diseases and immune disorders - ...

Fine-tuning a gene centrally involved in regulating the immune system offers potential clues for future autoimmunity and cancer treatments. The immune system faces a delicate balancing act: it must be ...

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein ...

On Wednesday afternoon, Haifan Lin, the director of the Yale Stem Cell Center, discussed his innovative research findings in stem cell gene expression and regulation at Brown’s 2025 Mac V. Edds ...