At the turn of the 20th century, bovine tuberculosis, a bacterial disease that infected cows and spilled over to humans via milk ran rampant in France. Today, a weakened form of that same ...

Monoclonal antibodies continue to show their ability to rid the brain of amyloid plaques. Trouble is, those antibodies need to be injected on the regular to keep taking down their targets in the brain ...

Epidemiological suggestions that the shingles vaccine might protect against dementia keep rolling in. Pascal Geldsetzer, Stanford University, presented his group’s latest findings at this year’s ...

Is it three steps forward one step back for blood tests? At the 18th Clinical Trials on Alzheimer’s Disease, held December 1–4 in San Diego, new data on the FDA-approved Fujirebio Lumipulse plasma ...

In Pick’s disease, as in Alzheimer’s disease and frontotemporal dementia, tangled tau spells trouble. In this subtype of FTD, abnormal clumps of three-repeat tau called Pick bodies abound in neurons.

Aβ and tau get much of the glory in Alzheimer’s disease, but the disease is far more complex than two proteins. Scientists know, for example, that lipid metabolism goes awry, but identifying ...

This is a knock-in (KI) mouse model carrying a L444P mutation in the endogenous Gba (glucocerebrosidase [GC] or acid β-glucosidase) gene (Liu et al., 1998). The GBA1 protein is the lipid-degrading ...

News Peptide Brace Against AD—Insulin, Neuropeptide Y Tame Aβ Toxicity 10 Feb 2009 Aβ and Phospho-tau: Strange Bedfellows Get Intimate at Synapses 19 Sep 2008 The Skinny on FAT: APP’s Role in Fast ...

Scientists have spotted a new variety of riled-up microglia that drives swelling in the human brain. In the November 18 Neuron, researchers from China led by Haixiao Liu, Shunnan Ge, and Yan Qu at ...

The days when reading a few papers brought scientists up to speed on the developments in their field are gone. Now scientists face mounting volumes of deeply complex datasets, and not remotely enough ...

How can scientists coax microglia to chew up more Aβ? In the November Alzheimer’s & Dementia, a group led by Rudolph Tanzi at Massachusetts General Hospital, Charlestown, revived an old idea. They ...

L444P KI mice were generated using a loxP replacement vector, resulting in the insertion of a point mutation of leucine to proline (L444P) in exon 10 of the Gba1 gene (Ginns et al., 2014). These Gba1 ...