Scientists create vast library of compounds to target disease proteins
Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits ...
Scientists glue two proteins together, driving cancer cells to self-destruct
The researchers developed a molecule that tethers BCL6 to ... that could target other cancer-driving proteins, including the ...
Nature10mon
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases
Ras proteins have been studied intensively since ... The generation of inhibitory versions of other types of signalling molecule, such as kinases, phosphatases and transcription factors, has ...
A potential advance against RAS-driven cancers—researchers find certain inhibitors can short-circuit mutation signals
In doing so, it acts as a molecular switch to turn "on" and ... These drugs work by preventing the interaction of RAS with ...
Detecting disease with only a single molecule
UC Riverside scientists have developed a nanopore-based tool that could help diagnose illnesses much faster and with greater ...
Nature6y
Regulation and crosstalk
HPO and Ras-associated domain family protein (RASSF) are mislocalized ... these papers uncover more molecular links between cell polarity, cell division and cell fate. Robinson et al.