Pharmacogenomics. 2014;15(11):1507-1518. MEK/CDK4 PD-0325901 (MEKi) + palbociclib (CDK4i) NCT02022982 MEK/CDK4 Trametinib (MEKi) + palbociclib (CDK4i) NCT02065063 ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Verastem Oncology is not just another biotech company; it is making significant strides in treating cancers driven by RAS/MAPK signaling pathways. Its focus is on novel small molecule drugs that ...

An NDA has been accepted by the FDA for the combination of avutometinib and defactinib in KRAS-mutated recurrent low-grade ...

Defactinib hydrochloride is under clinical development by Verastem and currently in Phase II for Non-Small Cell Lung Cancer.

Tonight will remain dry, and it will be another cold night with largely clear skies for much of the night. Towards dawn, areas of cloud will drift in from the west for some. Sunday Tomorrow will ...

After hours: January 3 at 6:42:39 PM EST Loading Chart for VSTM ...

Creation of all things; creation of Adam and Eve; temptation by Satan; Adam and Eve rebel against God and forfeit Garden of Eden. On that day, Adam and Eve, the father and mother of all mankind, chose ...

In recognising this UK Sport’s approach to funding reflects that journey and works on the basis of an athlete pathway with three clear and distinct levels that make up the World Class Pathway. The two ...

Insight blogs In the latest issue of AEROSPACE - January 2025 3 January 2025 In the January 2025 issue of AEROSPACE: Upset recovery training five years on, space - the year ahead, military helicopters ...