Figure 3: Various scaffolds utilized to engineer binders to Ras and their binding epitopes. Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated ...

Relapses in a common form of leukemia may be preventable following new research which has identified how the cancer develops resistance to first line treatments. New research published in iScience by ...

Researchers at the Francis Crick Institute and Vividion Therapeutics have identified chemical compounds that can precisely block the interaction between the major cancer-driving gene RAS, and a key ...

Proteins that are commonly mutated and overexpressed in cancers are called oncoproteins and are typical targets for cancer therapies. Cancer treatment faces significant challenges due to the presence ...

A research team led by MSK physician-scientist Dr. Piro Lito discovered that certain inhibitors can short-circuit the out-of-control signaling caused by mutations that fuel cancer growth. Each year, ...