Quanta Announces IND Clearance by U.S. FDA for QTX3544, an Oral G12V-Preferring Multi-KRAS Inhibitor, and Other Pipeline Updates
Additionally, the Phase 1 clinical trial evaluating QTX3034, an oral G12D-preferring multi-KRAS inhibitor, as a monotherapy and in combination with cetuximab, continues to enroll patients, and data is ...
Medscape1d
Early Intervention Central to Treating Muscle Mass Loss in Patients Losing Weight With GLP-1 Meds
Research showed that patients who lose weight on GLP-1 agonists frequently experience muscle mass loss. Obesity experts share ...
Nature1y
Capture Compounds for the functional isolation of nucleotide interacting proteins
and the monomeric small G proteins, which belong to the Ras superfamily of small GTPases. These proteins are homologous to the alpha subunit of heterotrimeric G proteins. Nearly 350 GPCRs are ...
Nature10mon
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases
This approach has been used extensively in the elucidation of signal-transduction cascades, such as those involving Ras-family proteins. Here I discuss the power and potential pitfalls of using ...