Despite sequence differences between subfamily members, all Ras-related proteins are GTPases with five ... Nature, 366, 634–654. Bollag G and McCormick F . (1995). Methods Enzymol., ...

Ras proteins have long been the focus of cancer ... in the recruitment of the oncogene KRas4b" is authored by Stephen G. Sligar, Michael C. Gregory and Mark A. McLean. It will be presented at ...

Ras proteins have long been the focus of cancer ... in the recruitment of the oncogene KRas4b" authored by Stephen G. Sligar, Michael C. Gregory and Mark A. McLean.

Using a new strategy, UC San Francisco researchers have succeeded in making small molecules that irreversibly target a mutant form of this protein, called ras, without binding to the normal form. This ...

In addition, the decline in muscle mass with GLP-1 RAs is several times greater than ... The recommended dietary allowance (RDA) for protein is 0.8 g/kg for most adults, while the acceptable ...

These proof-of-principle findings were published on Feb. 8 in Cell Reports. This work, which involves inhibiting the oncogenic protein RAS using small molecules, lays a strong foundation for the ...

These experiments revealed that by targeting RAS family proteins, using a small molecule inhibitor developed from a chemical library screen using the paratope of an inhibitory intracellular ...

A cancer-causing protein long thought to be resistant to medication could soon be the target of new drugs, thanks to the work of Quebec researchers who used synchrotron light to find and exploit ...

Renin–angiotensin system (RAS) inhibitors — including angiotensin ... or none), mean arterial pressure (<100 or ≥100 mm Hg), and proteinuria (protein:creatinine ratio, <885 or ≥885).