To demonstrate the power of their model, the researchers applied it to two biologically significant systems: the RAS-RAF complex and G Protein-Coupled Receptors (GPCRs). The RAS-RAF complex plays ...

Nutritional counseling remains a central component of obesity treatment, even in the era of highly effective weight-loss ...

Dr. Steven LaPlante, a professor at Quebec's Institut National de la Recherche Scientifique (INRS), and his team studied a type of protein called Ras, "which is highly related to a good percentage ...

this causes a conformational switch that allows Ras to engage downstream targets such as the Raf serine-threonine protein kinase. Membrane-based control of SOS activity The domain organization of ...

Combination treatment of QTX3544 with cetuximab significantly enhanced anti-tumor efficacy and elicited greater tumor regressions in pancreatic and colorectal KRAS G12V -mutant cell line-derived ...

Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins ...

Protein intake was individualized, but generally above the Dietary Reference Intake of 0.8 g/kg. They were assessed ... medications for use with GLP-1 RAs “will likely only be needed for ...