Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

The NF-κB-inducing kinase (NIK), a molecule pivotal for immune system development and function, shows significant yet complex potential as a therapeutic target. The comprehensive review, published by ...

In people destined to get Alzheimer's in their mid-40s, one protein can delay the onset of the disease by about 20 years.

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

A new experimental drug, Nerandomilast, has shown potential in reducing lung inflammation and fibrosis in preclinical models of Idiopathic Inflammatory Myopathy–Associated Interstitial Lung Disease ...

Crystal jellyfish have an eerie beauty: thanks to a natural protein, they emit a faint green glow. For decades, researchers ...

The biological mystery of how many mammals transitioned from being nocturnal to active in the daytime following the extinction of the dinosaurs has been cracked by researchers in Cambridge. The study, ...

Full-year 2025 revenue increased 10% year-over-year to $116.6 million, within revised guidance rangeFull year 2026 revenue guidance of $100.5 to ...

Boosting KCC2 function reduced seizures and abnormal brain activity in temporal lobe epilepsy models. Learn how this strategy could aid drug-resistant epilepsy.

A team of researchers has shown that noninvasive electrical stimulation of the vagus nerve through the ear can reverse memory ...

Osteoarthritis is usually framed as the price of just getting older. Many people imagine a knee that slowly wears down, then never recovers. That picture is familiar, yet it is too simple.

Northwestern Medicine scientists have discovered how calcium signaling channels in microglia—the primary immune cells of the brain—regulate neuroinflammation and promote the development of behaviors ...