To get the second quartz in the clinic, Grace will have to destroy a padlock and solve a puzzle in the Lead Researcher's Office in Resident Evil Requiem.

Find a way to unseal the door without a handwheel.

To open the unicorn door and get into the Parlor in Resident Evil Requiem, you have to: Get the Unicorn Trinket Box from the Chairman's Office. Examine the Unicorn Trinket Box to get the Red Jewel.