The Arizona Cardinals lost on Sunday in embarrassing fashion, a 45-17 drubbing from the Los Angeles Rams in front of the home fans at State Farm Stadium. They started playing well on offense, scoring 10 points in their first three drives, but then things fell apart as they didn't score again until it was 45-10.

WOODLAND HILLS, Ca. On Sunday, Los Angeles Rams wide receiver Puka Nacua was brilliant, hauling in seven catches for 167 yards and two touchdowns. Nacua's big day would be a massive factor in the Rams' blowout win over the Arizona Cardinals and his time in the end zone gave the superstar a career first.

Matthew Stafford was in peak form on Sunday, leading the Los Angeles Rams to a 45-17 rout of the Arizona Cardinals. Stafford, 37, threw for 281 yards and three touchdowns, while Puka Nacua and Blake Corum each scored twice as the Rams (10-3) poured in 35 unanswered points to rebound from last week’s turnover-marred loss to Carolina.

Jonathan Gannon admits the Cardinals were outplayed in every phase during a “humbling” loss to the Rams, their second five-game skid of 2025.

The Rams are an 8-point favorite over the Cardinals in NFL Week 14 odds for the game, courtesy of BetMGM Sportsbook. Los Angeles is -425 on the moneyline, while Arizona is +325. The over/under (point total) is set at 48.5 points.

The 9-3 Rams are tied for the best record in the NFC and are considered among the top teams to make a Super Bowl push. Meanwhile, the 3-9 Cardinals are already eliminated from the postseason and have a murky outlook entering the 2026 offseason.

The Los Angeles Rams pulled quarterback Matthew Stafford from the Week 14 game against the Arizona Cardinals early. Here's why.

Los Angeles Rams running back Blake Corum rushes for 17 yards against the Arizona Cardinals during their Week 14 matchup at State Farm Stadium.