When newly synthesized proteins translocate into the endoplasmic reticulum (ER) lumen, they undergo 'quality control'. An elaborate system of chaperones helps proteins to fold and prevents misfolded ...

Abnormalities in the structure of chromosomes within someone’s genetic makeup are called structural chromosomal abnormalities. Robertsonian translocations are very rare structural chromosomal ...

Figure 1: Hybrid-state model of translocation and experimental design. In the experiments described above, we could not resolve the first (counterclockwise) step from the second (clockwise) step of ...

Translocations, in genetics, happen when chromosomes break and the pieces attach to other chromosomes. This mixing of genetic material has important results. The resultant chromosomes are lacking in ...

Leukemia is an umbrella term for multiple different cancers that form in the blood, one such member of the leukemia family being chronic myelogenous leukemia (CML). CML is caused by a chromosomal ...