A potential advance against RAS-driven cancers—researchers find certain inhibitors can short-circuit mutation signals
In doing so, it acts as a molecular switch to turn "on" and ... These drugs work by preventing the interaction of RAS with ...
Scientists glue two proteins together, driving cancer cells to self-destruct
The researchers developed a molecule that tethers BCL6 to ... that could target other cancer-driving proteins, including the ...
News Medical1mon
New discovery reveals how mutant RAS genes drive tumor growth
Mutant RAS, they found, helps to kick off a series of events involving the transport of specific nuclear proteins that lead to uncontrolled tumor growth, according to a study published November 11 ...
Medscape6d
Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology
stimulating both the MAP-kinase signaling pathway and excessive prenylation of Ras and Rho proteins (Fig. 1). Therefore, treatment of insulin-resistant individuals must include effective measures ...
Scientific American3y
Targeting the Toughest Signaling Pathway in Cancer
A lethal, mutant version of the KRAS signaling enzyme was often called undruggable—until researchers found a molecule that has the potential to lock onto this cancer-causing protein.
Nature9mon
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases
Ras proteins have been studied intensively since ... The generation of inhibitory versions of other types of signalling molecule, such as kinases, phosphatases and transcription factors, has ...
Labroots11y
Oncoproteins K-Ras and Pim kinases as molecular targets in pancreatic cancer
The presence of oncogenically mutated K-Ras in 90% of human pancreatic ductal adenocarcinomas (PDAC) strongly suggests a critical role for this genetic mutation in the development of this disease. We ...