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Researchers from Bochum and Osnabrück have gained new insights into the structure of the Ras protein, which acts as a molecular switch for cell growth and is involved in the development of cancer.
Researchers from Bochum and Osnabrück have gained new insights into the structure of the Ras protein, which acts as a molecular switch for cell growth and is involved in the development of cancer.
Bochum biophysicists in collaboration with the MPI Dortmund have for the first time measured the orientation of the Ras protein bound to the cell membrane. The RUB team combined the use of three ...
KRAS is one of the most frequently activated proteins in cancer, yet the development of RAS inhibitors has proven to be extremely challenging. Here, Shokat and Ostrem discuss the latest insights ...
Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations. Proceedings of the National Academy of Sciences , 2012; 109 ...
Iambic to receive up to $25 million through a combination of upfront and expected near-term performance-based milestone payments for services related to Revolution Medicines’ access to Iambic’s ...
Mutated RAS proteins can become stuck in an uncontrollable, "always on" growth state. This state is indicated in the formation of about 30 percent of all cancers, ...
The study, published in Nature Structural & Molecular Biology, focuses on a family of proteins called RAS, which is mutated in 20 to 25% of all cancers, especially in lethal cancers such as ...
Due to their structure lacking deep drug-binding sites or having a large smooth surface, traditional inhibitors cannot successfully bind to and block or degrade the protein. Many off-target effects ...