Malfunctions of the Ras protein can cause it to remain in an active state or switch off with a significant delay. This causes uncontrolled cell growth and, as a result, cancer.

Researchers from Bochum and Osnabrück have gained new insights into the structure of the Ras protein, which acts as a molecular switch for cell growth and is involved in the development of cancer.

Scientists at the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute have determined the molecular structure of a RAS-pathway protein called SHOC2 and two other proteins it ...

Analysis of RAS structure and dynamics suggests that targeting ... Stabilizing non-productive protein–protein complexes remains an attractive approach to inhibiting RAS; however, little progress ...

Figure 1: Domain structure of the Ras proteins. Models of plasma-membrane microstructure have also been evolving rapidly over the past 5–6 years. The plasma membrane is no longer considered to ...

Mutated Ras is involved in tumor formation ... If the spectra obtained with both techniques match, the structure of proteins can be determined to an accuracy of a millionth of a micrometre.

An expert in proteins and director of Northwestern's Proteomics Center of Excellence, Kelleher has developed a new technology that can—in precise detail—detect and quantify the effect of RAS ...

Mutated Ras is involved in tumour formation ... If the spectra obtained with both techniques match, the structure of proteins can be determined to an accuracy of a millionth of a micrometre. This was ...

Ras proteins have long been the focus of cancer research because of their role as "on/off switch" signaling pathways that control cell division and failure to die like normal, healthy cells do. In ...