Malfunctions of the Ras protein can cause it to remain in an active state or switch off with a significant delay. This causes uncontrolled cell growth and, as a result, cancer.

Researchers from Bochum and Osnabrück have gained new insights into the structure of the Ras protein, which acts as a molecular switch for cell growth and is involved in the development of cancer.

Figure 1: Domain structure of the Ras proteins. Models of plasma-membrane microstructure have also been evolving rapidly over the past 5–6 years. The plasma membrane is no longer considered to ...

Analysis of RAS structure and dynamics suggests that targeting ... Stabilizing non-productive protein–protein complexes remains an attractive approach to inhibiting RAS; however, little progress ...

Orientation affects protein interactions The orientation ... An understanding of the stereo structure of Ras will allow us to adopt novel approaches in drug development. "So far, no drugs have ...

"Our ultimate goal is to identify novel pockets that transiently open during protein motion but are hidden in the average experimental Ras structure so that we can target those," Srivastava said.

Mutated Ras is involved in tumor formation ... If the spectra obtained with both techniques match, the structure of proteins can be determined to an accuracy of a millionth of a micrometre.

Mutated Ras is involved in tumour formation ... If the spectra obtained with both techniques match, the structure of proteins can be determined to an accuracy of a millionth of a micrometre. This was ...

Due to their structure lacking deep drug-binding sites or having ... A key example of undruggable oncoproteins is the Ras family of proteins, a key player in many cancer pathways. Small-molecule ...