MAP2K1/MEK1 mutations are potentially actionable drivers in cancer. MAP2K1 mutations have been functionally classified into three groups according to their dependency on upstream RAS/RAF signaling.

SHP2 is an important protein mediator of cellular signaling through RAS/MAP kinase pathway. Many tumors have genetic mutations, driving abnormal cancer cell growth which relies on SHP2 activity.

Abstract #: 4394 Session: RAS Inhibitors, Experimental and Molecular Therapeutics Location/Poster Board #: Poster Section 21, Board # 29 Date and Time: April 29, 2025 from 9:00 am to 12:00 pm CST ...

SHP2 is an important protein mediator of cellular signaling through RAS/MAP kinase pathway. Many tumors have genetic mutations, driving abnormal cancer cell growth which relies on SHP2 activity.

The promise of the SHP2 inhibitor centered on its ability to tackle the RAS-MAP kinase pathway, where research suggested the SHP2 enzyme contributed to the oncogenic traits of some mutated proteins.

Topline Summary Erasca, Inc. (ERAS) is a developmental biotech operating almost entirely in the space of developing novel targeted therapies against the RAS/MAP kinase pathway in solid tumor oncology.

Of these, receptor tyrosine kinase (RTK) pathways are some of the best explicated. 14,18,34 Extracellular ligand-binding stimulates homo- and/or heterodimerization of RTKs, causing kinase activity ...

When cells were stimulated with a common growth factor, hSef interacted with activated ERK in the cytoplasm. The inhibitor was only switched on when the Ras/ERK MAP kinase pathway was activated.

Collectively, this group of conditions is now termed RASopathies, since all subsequent studies confirmed both the originally identified cell signaling pathway—termed RAS-MAP kinase—as well as ...

Certain rationally based combinations, for example, using PI3 kinase together with MEK inhibitors that block the important RAS-RAF-MEK MAP kinase pathway, have obvious mechanistic rationale and these ...

Turning Points Published: 03 October 2012 Pathway discovery: The road to Ras and MAP kinase Chris Marshall Nature Cell Biology 14, 978 (2012) Cite this article ...