Once activated, Ras can do a variety of things. In this example, it activates an enzymatic cascade of MAP kinases ... activates an enzyme called a kinase. Learn how kinases initiate a signaling ...

The effective targeting of RAS-mutant acute myeloid leukemia (AML) still remains a challenge; RAS mutations are tied to relapse to targeted therapy, such as resistance to FLT3 inhibitors due to the ...

In contrast, the signal proceeds normally or with greater strength (because of compensatory hyperinsulinemia of various degrees) along the Shc-Ras-MAP kinase pathway, eliciting greater responses ...

Using this technique, they were able to identify known and novel protein interactions linking the epidermal growth factor receptor with the Ras/MAP kinase signaling pathway (see p. 1193).