Each year, more than 3 million people are diagnosed with cancers driven by mutations in three RAS-family genes: KRAS, NRAS, ...

Over 35 years ago, a group led by Dr. Lowy contributed to the early studies that identified RAS as a cancer-causing gene and helped explain how it promotes tumor growth. In this new study, the ...

RAS genes are the second most frequently mutated genes in cancer, and mutant RAS proteins are key drivers of some of the deadliest cancers, including nearly all pancreatic cancers, half of ...

It causes mutations in the p53 tumor-suppressor gene as well as ras mutations, which are involved in the majority of human cancers. Aflatoxin has been shown to contaminate tobacco products.

Once activated, Ras can do a variety of things ... such as the alteration of key proteins and changes in gene transcription. Signal binding to membrane receptor tyrosine kinases (RTKs) activates ...

RAS proteins are important growth signal transducers, and mutations affecting RAS genes are found in over 30% of tumors. One of our major projects is to better define how ER and RAS are connected, ...

(B) Incidence of BRAF mutations and co-occurring mutations in any RAS gene. (C) Incidence of co-occurring KRAS and PIK3CA mutations.

We discovered one of the major ways by which RAS oncogenes cause normal cells to become cancerous – and identified new targets for cancer treatment. Scientists at The Institute of Cancer Research led ...

PAX8-PPAR γ and RAS mutations tend to correlate with specific phenotypical features of follicular carcinomas. Targeted therapy for thyroid cancer with BRAF and RET inhibitors has progressed to ...

The new drug, called CH5126766/VS6766, blocks the effect of mutated genes from the signalling pathway in multiple places within a cancer cell, making it different from other efforts to find treatments ...

RAS genes are the second most frequently mutated genes in cancer, and mutant RAS proteins are key drivers of some of the ...