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WASHINGTON, D.C., Feb. 18, 2018 -- Protein systems, such as Ras, make up the complex signaling pathways that control whether a cell divides or, in some cases, becomes cancerous and metastasizes ...
Normally, RAS receives and follows signals to switch between active and inactive states, but as the proteins move along the cell membrane - like balls of string tumbling along a fluid ground ...
Malfunctions of the Ras protein can cause it to remain in an active state or switch off with a significant delay. This causes uncontrolled cell growth and, as a result, cancer.
Ras undergoes several posttranslational modifications that facilitate its attachment to the inner surface of the plasma membrane. The first—and most critical—modification is the addition of a farnesyl ...
"Targeting RAS proteins may prevent relapse in Acute Myeloid Leukemia." ScienceDaily. ScienceDaily, 9 April 2024. <www.sciencedaily.com / releases / 2024 / 04 / 240409124036.htm>.
Optimizing Stability of Engineered Anti-RAS bioPROTAC for Rapid Degradation of Undruggable Proteins Thursday, June 5, 2025 11:00 AM-1:00 PM BIOMED Master's Thesis Defense Title: Optimizing Stability ...