RTKs can activate Ras, a protein that is tethered to the plasma membrane, by causing it to bind GTP. Once activated, Ras can do a variety of things. In this example, it activates an enzymatic ...

PAIRING UP Some proteins encoded by RAS genes appear to function as dimers—linked pairs of identical molecules. Pasi Jänne, a medical oncologist at Dana-Farber Cancer Institute, used a fluorescence ...

and the monomeric small G proteins, which belong to the Ras superfamily of small GTPases. These proteins are homologous to the alpha subunit of heterotrimeric G proteins. Nearly 350 GPCRs are ...