Adenosine deaminase 2 deficiency (DADA2) is a rare, monogenic autoinflammatory disorder caused by biallelic mutations in the CECR1 gene, which encodes the ADA2 protein. This condition is characterised ...

Please provide your email address to receive an email when new articles are posted on . T-receptor excision circle screenings can miss cases of adenosine deaminase deficiency (ADA), which can be fatal ...

Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its role ...

Please provide your email address to receive an email when new articles are posted on . Including tandem mass spectroscopy in newborn screenings to identify adenosine deaminase deficiencies could save ...

An investigational gene therapy showed sustained clinical efficacy for children born with ADA-SCID. In a study of 62 children, overall survival after treatment was 100% and event-free survival was 95% ...

Adenosine deaminase 2 (ADA2) plays a critical role in immune regulation, particularly in monocyte differentiation and activation. Unlike ADA1, which primarily functions intracellularly, ADA2 can be ...

Severe combined immunodeficiency due to adenosine deaminase deficiency, or ADA-SCID, is caused by mutations in the ADA gene, which creates an enzyme essential for immune function. For children with ...