The San Francisco 49ers were expected to beat the Tennessee Titans, and they were expected to do it by about two scores.

San Francisco 49ers wide receiver Ricky Pearsall was briefly knocked out of Sunday's game against the Titans by an illegal tackle that wasn't penalized by the referees.

SANTA CLARA — Christian McCaffrey will continue his two-pronged assault on a 49ers’ playoff berth as well as his quest to become the first player in NFL history to have two separate seasons of 1,000 yards rushing and receiving.

Preview the Week 15 matchup between the San Francisco 49ers and Tennessee Titans with predictions, odds, over/under, spread, betting lines and more.

Christian McCaffrey shared how the "selfless" 49ers offense is finding success after San Francisco's Week 15 win over the Tennessee Titans on Sunday.

Brock Purdy threw a one-yard TD to George Kittle that extended the San Francisco 49ers lead to 31-10 over the Tennessee Titans.