The Rogue Valley is a valley region in southwestern Oregon in the United States. Located along the middle Rogue River and its tributaries in Josephine and Jackson counties, the valley forms the cultural and economic heart of Southern Oregon near the California border. The largest communities in the Rogue Valley are Medford, Ashland and Grants P…The Rogue Valley is a valley region in southwestern Oregon in the United States. Located along the middle Rogue River and its tributaries in Josephine and Jackson counties, the valley forms the cultural and economic heart of Southern Oregon near the California border. The largest communities in the Rogue Valley are Medford, Ashland and Grants Pass. The most populated part of the Rogue Valley is not along the Rogue proper, but along the smaller Bear Creek tributary.