Downtown Detroit is the central business district and a residential area of the city of Detroit, Michigan, United States. Locally, "downtown" tends to refer to the 1.4 square mile region bordered by M-10 to the west, Interstate 75 to the north, I-375 to the east, and the Detroit River to the south. It may also be used to refer to the Greater Downtown area, a 7.2 square mil…Downtown Detroit is the central business district and a residential area of the city of Detroit, Michigan, United States. Locally, "downtown" tends to refer to the 1.4 square mile region bordered by M-10 to the west, Interstate 75 to the north, I-375 to the east, and the Detroit River to the south. It may also be used to refer to the Greater Downtown area, a 7.2 square mile region that includes surrounding neighborhoods such as Midtown, Corktown, Rivertown, and Woodbridge.