Homepage | Archives of Disease in Childhood
WEBArchives of Disease in Childhood (ADC) is an international and peer-reviewed journal specialising in child health, covering the perinatal period through to adolescence. As an official journal of the Royal College of Paediatrics and Child Health, ADC provides paediatricians with the most recent, relevant and original research reports ...
Fetal alcohol spectrum disorders: an overview of current evidence …
WEBEstimates for the UK suggest that alcohol consumption during pregnancy and prevalence of fetal alcohol spectrum disorder (FASD)—the most common neurodevelopmental condition—are high. Considering the significant health and social impacts of FASD, there is a public health imperative to prioritise prevention, interventions and support. In this article, we outline the current state of play ...
Current evidence-based recommendations on investigating …
WEBIntroduction Global developmental delay (GDD) affects 1%–3% of the population of children under 5 years of age, making it one of the most common conditions presenting in paediatric clinics; causes are exogenous, genetic (non-metabolic) or genetic (metabolic). Recent advances in biotechnology and genetic testing mean that the investigations available to perform for children under 5 years are ...
Understanding randomised controlled trials | Archives of Disease …
WEBThe hierarchy of evidence in assessing the effectiveness of interventions or treatments is explained, and the gold standard for evaluating the effectiveness of interventions, the randomised controlled trial, is discussed. Issues that need to be considered during the critical appraisal of randomised controlled trials, such as assessing the validity of trial methodology and the magnitude and ...
Tachypnoea in a well baby: what to do next? | Archives of Disease …
WEBAdditionally symptoms will be milder if it is a stenosis rather than complete atresia. Techniques for diagnosis include placing a cold mirror/metal spoon under the nostril to look for condensation, passing a small nasogastric tube, or putting a few drops of saline in the nostril and looking for bubbles. 29.
Prescribing for children - Archives of Disease in Childhood
WEBThe taste of an antibiotic is often not taken into account by practitioners, although there is significant evidence to show palatability correlates strongly with adherence. Many parents will be familiar with the difficulties of convincing young children to take bitter, unfamiliar medicine. Certain drugs, for example flucloxacillin, are so unpalatable that they should not be prescribed as ...
Cardiovascular effects of mechanical ventilation
WEBThe influence of ventilation on cardiac function. Spontaneous and mechanical ventilation induce changes in intrapleural or intrathoracic pressure and lung volume, which can independently affect the key determinants of cardiovascular performance: atrial filling or preload; the impedance to ventricular emptying or …
Purpura fulminans: recognition, diagnosis and management
WEBPurpura fulminans (PF) is a haematological emergency in which there is skin necrosis and disseminated intravascular coagulation. This may progress rapidly to multi-organ failure caused by thrombotic occlusion of small and medium-sized blood vessels. PF may complicate severe sepsis or may occur as an autoimmune response to otherwise benign childhood infections. PF may also be the presenting ...
Authors - Archives of Disease in Childhood
WEBAuthors who submit to Archives of Disease in Childhood and are rejected will be offered the option of transferring to BMJ Paediatrics Open. BMJ Paediatrics Open is the open access companion journal to Archives of Disease in Childhood. It is indexed by PubMed Central, Scopus, Embase, DOAJ, and Google Scholar, and publishes articles dealing with ...
Investigating microcephaly - Archives of Disease in Childhood
WEB1. Microcephaly is a clinical finding, not a ‘disease’, and is a crude but trusted assessment of intracranial brain volume. 2. Developmental processes reducing in utero neuron generation present at birth with ‘Primary microcephaly’. 3. ‘Secondary microcephaly’ develops after birth and predominantly reflects dendritic or white matter diseases. 4. Microcephalic conditions have a ...