Norovirus Vaccine against Experimental Human Norwalk Virus …
WEBDec 8, 2011 · We conducted a randomized, double-blind, placebo-controlled, multicenter trial to assess the safety, immunogenicity, and efficacy of an investigational, intranasally delivered norovirus...
Atomic structure of the predominant GII.4 human norovirus capsid ...
WEBMar 10, 2022 · Human noroviruses (HuNoVs) cause sporadic and epidemic viral gastroenteritis worldwide. The GII.4 variants are responsible for most HuNoV infections, and GII.4 virus-like particles (VLPs) are ...
Human norovirus targets enteroendocrine epithelial cells in the …
WEBJun 2, 2020 · One such cell bearing an aggregated negative-strand RNA signal (Fig. 2e, white arrow) was shown by 3D imaging to contain cytokeratin (Supplementary Movie 1), suggesting an epithelial origin.
Genome-wide analyses of human noroviruses provide insights on …
WEBJul 13, 2021 · In this multinational collaborative study, we mined archival samples collected since the 1970s and sequenced nearly full-length new genomes from 281 historical noroviruses, including the first full-length genomic sequences for three genotypes.
Norovirus protein structure and function - Oxford Academic
WEBDec 1, 2005 · Norwalk virus nonstructural protein p48 forms a complex with the SNARE regulator VAP-A and prevents cell surface expression of vesicular stomatitis virus G protein.
Human Norovirus Proteins: Implications in the Replicative Cycle ...
WEBJun 15, 2020 · The HuNoV replicative cycle starts with the interaction of the virus with the target cell through the recognition of specific cellular receptors and, in some cases, other cellular components. In the case of HuNoV, the main receptor is still unknown.
Viral shape-shifting: norovirus evasion of the human immune …
WEBFeb 2, 2010 · This work shows that recombinant Norwalk virus capsid proteins can self-assemble into virus-like particles using the baculovirus expression system.
Adjuvanted Intranasal Norwalk Virus-Like Particle Vaccine Elicits ...
WEBDec 1, 2010 · Adjuvanted Intranasal Norwalk Virus-Like Particle Vaccine Elicits Antibodies and Antibody-Secreting Cells That Express Homing Receptors for Mucosal and Peripheral Lymphoid Tissues | The Journal of Infectious Diseases | Oxford Academic. Journal Article.
Norovirus Gastroenteritis | New England Journal of Medicine
WEBOct 29, 2009 · The Norwalk agent was the first virus that was identified as causing gastroenteritis in humans, but recognition of its importance as a pathogen has been limited because of the lack of available,...
STAT1-Dependent Innate Immunity to a Norwalk-Like Virus
WEBNorwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus.